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Epub 2012 Apr 19
DYRK1-IN-1 inhibits tau phosphorylation with an IC50 value of 0
351(3):674-84
InChiKey: SCULJPGYOQQXTK-OLRINKBESA-N
When using [3H]5-HT as a radioligand
Safingol Catalog No.:M22674-C Epub 2012 Apr 19Ki: SphK with a Ki of about 5 mol L Safingol is a sphingosine and PKC kinases inhibitor. Sphingosine 1 phosphate, a product of sphingosine kinases (SphK), mediates various biological processes including cell proliferation, differentiation, motility, and apoptosis. Protein kinase C (PKC), is a family of protein kinase enzymes involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine
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