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10bR)-8-chloro-4-methyl-1H
16-trihydroxy-18-methoxy-12-methyl-3
known as D and L
24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells
BMS-819881 also is selective and potent for CYP3A4 activity with an EC50 of 13 μM
BI-882370 evodopa 10bR)-8-chloro-4-methyl-1HBI 882370 is a potent and selective RAF kinase inhibitor that binds to the ATP binding site of the kinase positioned in the DFG out (inactive) conformation of the BRAF kinase. BI 882370 (BI 882370) inhibits the oncogenic BRAFV600E mutant, the WT BRAF and CRAF kinases with IC50s of 0. 4, 0. 8, and 0. 6 nM, respectively. BI 882370 also inhibits SRC family kinases. Product information CAS Number: 1392429 79 6 Molecular Weight: 569. 67 Formula:
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