Almonertinib Catalog No.:M23836-C COC1C=C2N=CC=C(OC3C=CC(=CC=3)NC(=O)CC3C=C(C(Cl)=CC=3)C(F)(F)F)C2=CC=1OC

COC1C=C2N=CC=C(OC3C=CC(=CC=3)NC(=O)CC3C=C(C(Cl)=CC=3)C(F)(F)F)C2=CC=1OC

it increases Alkaline phosphatase (ALP) activity in MC3T3-E1 cells in a concentration-dependent manner

which suggested that ARC 239 recognized 5-HT1A receptor

Nesland JM

Wuweizichun-B

Almonertinib Catalog No.:M23836-C COC1C=C2N=CC=C(OC3C=CC(=CC=3)NC(=O)CC3C=C(C(Cl)=CC=3)C(F)(F)F)C2=CC=1OCAlmonertinib (HS 10296) is an orally available, irreversible, third generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M L858R and T790M Del19 (IC50: 0. 37, 0. 29 and 0. 21 nM, respectively), and is less effective against wild type (3. 39 nM). Almonertinib is used for the research of the non small cell lung cancer. Product