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PubMed Central PMCID: PMC4275380
It inhibits LSD1 in biochemical assay with an IC50 ~16 nM
DASA-58 was used at 1-10 µM final concentration in various assays
3-dioxygenase (IDO1) inhibitor with IC50 ~10 nM It displays high selectivity over other related enzymes such as IDO2 or tryptophan 2
InChi: InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H
GSK-LSD1 - LSD1 Inhibitor. CAS# 2102933-95-7 0073 PubMed Central PMCID: PMC4275380GSK LSD1, CAS No. 2102933 95 7, is a highly potent, specific and irreversible inhibitor of Lysine Specific Demethylase 1 (LSD1). It inhibits LSD1 in biochemical assay with an IC50 ~16 nM, and is > 1000 fold selective over other closely related FAD utilizing enzymes (i. e. LSD2, MAO A, MAO B). GSK LSD1 induces gene expression changes in cancer cell lines (average EC50 < 5 nM) and inhibits cancer cell line growth (average EC50 < 5 nM). Product
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