AKR1C3-IN-4 13633 2-oxazinan-2-yl)-1-oxopropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-2-oxoethyl)-4-((S)-sec-butyl)-7

2-oxazinan-2-yl)-1-oxopropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-2-oxoethyl)-4-((S)-sec-butyl)-7

but fails to block carbachol (CCh)–induced TRPC4 and OAG-induced TRPC6 currents

Solubility: DMSO : 190 mg/mL (406

1445251-22-8

Smiles: CC(C)(CO)C1=CC=C(C=C1)S(=O)(=O)NC1=NC(=NC(OCCO)=C1OC1=CC=CC=C1O)C1=NC=CC=N1

AKR1C3-IN-4 13633 2-oxazinan-2-yl)-1-oxopropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-2-oxoethyl)-4-((S)-sec-butyl)-7AKR1C3 IN 4 is a potent and selective aldo keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 0. 56 M. AKR1C3 IN 4 has the potential for castrate resistant prostate cancer (CRPC) research. Product information CAS Number: 1284180 11 5 Molecular Weight: 281. 23 Formula: C14H10F3NO2 Chemical Name: 3 {[4 (trifluoromethyl)phenyl]amino}benzoic acid Smiles: OC(=O)C1=CC(=CC=C1)NC1C=CC(=CC=1)C(F)(F)F InChiKey: MDZIRNPRVJEHHX UHFFFAOYSA N InChi: InChI=1S