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PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase
selective and cell-permeable p300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 ~400 nM
β-apo-13-carotenone antagonizes 9cRA activation of full-length hRXRα with a similar efficiency as the known antagonist UVI3003
and can be used in the treatment of various diseases
Chemical Name: N-((1r
TAK-659 3992 PR-104A is metabolized under hypoxiaTAK 659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3. 2 nM and 4. 6 nM for SYK and FLT3, respectively. TAK 659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL). Product information CAS Number: 1312691 33 0 Molecular Weight: 344. 39 Formula:
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