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GDC-0077 - CAS# 2060571-02-8 Catalog No.:M17007-C iridoid glycoside from Corni Fructus

SKU: 4493873377

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Description

iridoid glycoside from Corni Fructus

InChi: InChI=1S/C22H18F2N4O3S/c1-12(2)32(30

Bax and Bcl-2 expressions in HT22 cells medaited by rmMFG-E8 in the co-cultured cells under OGD condition

CREBtide (KRREILSRRPSYR)

Formula: C42H56F2N8O6

GDC-0077 - CAS# 2060571-02-8 Catalog No.:M17007-C iridoid glycoside from Corni FructusGDC 0077 (RG6114) is a potent selective inhibitor of PI3K alpha (PI3K) with an IC50 of 0. 038 nM. GDC 0077 is >300 fold more selective for PI3K alpha over the other class I PI3K isoforms (beta, delta, and gamma) and >2000 fold more selective over PIK family members. GDC 0077 binds to the ATP binding site of PI3K and inhibits the phosphorylation of PIP2 to PIP3. Product information CAS Number: 2060571 02 8 Molecular Weight: 407. 37 Formula:

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