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PMCID: PMC6063991
PubMed PMID: 22001744
GW501516 is shown to be the most potent and selective PPARα agonists known with an EC50 of 1
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
As a transcription factor that regulates cell cycle and pigmentation
Entrectinib - CAS# 1108743-60-7 size:10mg solid PMCID: PMC6063991Entrectinib, CAS No. 1108743 60 7, also known as RXDX 101 and NMS E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. RXDX 101 has demonstrated potent pharmacological activity in preclinical studies and has the potential to be first in class against the Trk family of kinases. PXDX 101 has been well tolerated in patients with advanced solid tumors. PXDX 101 is currently in
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