LLY-507 - Protein-lysine Methyltransferase SMYD2 Inhibitor. CAS# 1793053-37-8 Asn-PAB-PNP CAS Number: 103404-90-6

CAS Number: 103404-90-6

Smiles: CS(=O)(=O)N(CC(O)CN1C2=CC=CC=C2C2=CC=CC=C12)CC1=CC=CO1

the genes coding for isocitrate dehydrogenases 1 and 2

InChi: InChI=1S/C21H22N2O4S/c1-28(25

CAS Number: 670220-88-9

LLY-507 - Protein-lysine Methyltransferase SMYD2 Inhibitor. CAS# 1793053-37-8 Asn-PAB-PNP CAS Number: 103404-90-6LLY 507, CAS No. 1793053 37 8, is a potent, selective and cell permeable protein lysine methyltransferase SMYD2 inhibitor with IC50 <15 nM. It binds in the substrate peptide binding pocket. It has >100 fold selectivity over other methyltransferases and other non epigenetic targets. LLY 507 has been shown to inhibit p53K370 monomethylation in cells with an IC50 ~600 nM. It inhibited the proliferation of several esophageal, liver, and breast cancer cell