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InChi: InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16
As an agonist of the KOR
with 50 nM PU-H71 needed to significantly reduce the LPS dependent nitrite release
GDC-0084 exhibited Ki values of 2 nM
InChiKey: YCIOJDKGCWAHLR-UHFFFAOYSA-N
Chymostatin 4885614 InChi: InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16Chymostatin is a bioactive peptide of microbial origin that acts as a protease inhibitor with selectivity for chymotryptase like serine proteases. It potently inhibits chymotrypsin and chymase (Ki = 9. 36 and 13. 1 nM, respectively) while less effectively blocking the activity of cathepsins, papain, and leukocyte elastase.,,,, It is without effect on trypsin, thrombin, plasmin, pepsin, and kallikrein. Product information CAS Number: 9076 44 2