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It is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0
Smiles: O=C(NCC1C=CC=CC=1)C1=CSC(NC2=CC=NC=N2)=N1
CAS Number: 1331782-27-4
Formula: C18H18F3NO4
Chemical Name: N-[3-[3-[4-[(Dimethylamino)methyl]phenyl]pyrazolo[1
Afobazole Hydrochloride - CAS# 173352-39-1 Catalog No.:M11224-C It is an irreversible tyrosine-kinaseFabomotizole, also known as Afobazole, is an anxiolytic drug launched in Russia in the early 2000s. It produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions. Its mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor agonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Fabomotizole was shown to inhibit MAO A reversibly
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