K-Ras ligand-Linker Conjugate 4 Catalog No.:M14597-2 Pyridone 6 interferes with JAK

Pyridone 6 interferes with JAK kinase activity by interacting within the ATP-binding cleft

InChi: InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27

CC1=CN=C(CS(=O)C2[N-]C3=CC=C(C=C3N=2)OC)C(C)=C1OC

InChi: InChI=1S/C47H76O16/c1-22-30(50)33(53)35(55)38(59-22)62-37-34(54)32(52)26(20-48)60-40(37)63-36-31(51)25(49)21-58-39(36)61-29-12-13-44(6)27(43(29

InChi: InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15

K-Ras ligand-Linker Conjugate 4 Catalog No.:M14597-2 Pyridone 6 interferes with JAKK Ras ligand Linker Conjugate 4 incorporates a ligand for K Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K Ras ligand Linker Conjugate 4 can be used in the synthesis of PROTAC K Ras Degrader 1 (HY 129523), which is potent PROTAC K Ras degrader that exhibits 70% degradation efficacy in SW1573 cells. Product information CAS Number: 2378261 83 5 Molecular Weight: 697. 82 Formula: C35H51N7O8