BI-3663, PTK2/FAK PROTAC 632 Smiles: COC1=CC(Cl)=C(I)C=C1NCC(=O)N1CCC(CC1)NS(=O)(=O)C=C

Smiles: COC1=CC(Cl)=C(I)C=C1NCC(=O)N1CCC(CC1)NS(=O)(=O)C=C

InChiKey: UCUHFWIFSHROPY-RWPZCVJISA-N

protein synthesis

A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination

Carceller V

BI-3663, PTK2/FAK PROTAC 632 Smiles: COC1=CC(Cl)=C(I)C=C1NCC(=O)N1CCC(CC1)NS(=O)(=O)C=CBI 3663 is a highly selective PTK2 FAK PROTAC (DC50=30 nM), with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI 3663 inhibits PTK2 with an IC50 of 18 nM. BI 3663 is a PROTAC that composes of BI 4464 (HY 124625) linked to Pomalidomide (HY 10984) with a linker. Anti cancer activity. Product information CAS Number: 2341740 84 7 Molecular Weight: 917. 84 Formula: C44H42F3N7O12 Chemical Name: N [2 (2, 6 dioxopiperidin 3 yl) 1, 3 dioxo 2, 3